Melanosis oculi (ocular
melanocytosis) is a congenital blue nevus of the
episclera and sclera associated with increased
pigmentation of the uveal tract. Multiple gray pathces are seen in the sclera
and episclera, and the ipsilateral iris and fundus are
darker than those of the unaffected eye.
Melanosis oculi with
melanosis of the ipsilateral eyelid skin is referred to
as oculodermal melanocytosis (nevus of Ota).
The most serious
complication of the oculodermal melanocytosis is
malignant transformation, although this is rare and seems
to occur only in white patients. Malignant transformation
in the skin, conjunctiva, orbit, and meninges is possible
but rare.
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